Givaudan Active Beauty launches PrimalHyal™ UltraReverse

Givaudan Active Beauty is delighted to unveil PrimalHyal™ UltraReverse – the smallest and most sustainable hyaluronic acid ever developed. This active ingredient has the unique ability to penetrate skin cells and act at the DNA level, effectively addressing most of the primary hallmarks of ageing. By tackling ageing at its root, PrimalHyal™ UltraReverse is set to redefine the ‘well-ageing’ experience.

PrimalHyal™ UltraReverse, the intracellular hyaluronic acid, targets four of the five primary hallmarks of ageing:
 

• Epigenetic control: restoring DNA methylation processes and enhancing sirtuins expression and activity, limiting cryptic transcription.
• Genomic instability: amplifying DNA repair mechanisms for a healthier skin.
• Telomeres attrition: reactivating telomerase expression and activity, protecting the chromosomes integrity.
• Loss of proteostasis: boosting the proteasome activity to ensure optimal cellular function.

By targeting these biological pathways, PrimalHyal™ UltraReverse protects the skin not only from chronological ageing, but also from environmental stressors known as the exposome. 

It increases sirtuin 1 by +136% and improves collagen 1 production by +48%, helping to restore skin’s youthfulness. The result? 

Visibly younger, healthier skin, with an apparent age reduced by up to six years. It also corrects key signs of ageing, including wrinkles and sleep lines while offering improved skin firmness, as demonstrated on a diverse and international panel of volunteers.

“Building on the expertise of PrimalHyal™ 50 Life, strain engineering experts at Alderys have designed PrimalHyal™ UltraReverse, an ultra-low molecular weight hyaluronic acid, lower than 3 kDa, that unlocks new biological benefits. Produced by precision fermentation, its environmental impact is drastically reduced – setting a new benchmark for sustainable, high-performance skincare.”

Romain Reynaud, Research & Development Director

 

“Longevity has become a key trend in the beauty industry, driven by growing consumer interest in prevention and a holistic approach to skin health. In fact, 84% of people agree that they should embrace their age rather than trying to hide it, underlining the move towards a more authentic perspective on ageing¹. Givaudan Active Beauty emphasises that true skincare is not just about appearance, but about longevity, prevention and wellbeing, by offering solutions that preserve the skin’s health capital.”

Mathias Fleury, Head of Category Active ingredients

To learn more about our new ingredient and its marketing concept, S3D® Reverso, we invite you to visit us at our booth #1B120 at in-cosmetics Global, taking place in Amsterdam, the Netherlands. Or connect to uxbeauty.givaudan.com, our digital platform dedicated to cosmetic ingredients. 

1. Givaudan in-house anti-ageing consumer study

About Givaudan
Givaudan is a global leader in Fragrance & Beauty and Taste & Wellbeing. We celebrate the beauty of human experience by creating for happier, healthier lives with love for nature. Together with our customers we deliver food experiences, craft inspired fragrances and develop beauty and wellbeing solutions that make people look and feel good. In 2024, Givaudan employed over 16,900 people worldwide and achieved CHF 7.4 billion in sales with a free cash flow of 15.6%. With a heritage that stretches back over 250 years, we are committed to driving long-term, purpose-led growth by improving people’s health and happiness and increasing our positive impact on nature. This is Givaudan. Human by nature. Discover more at: www.givaudan.com.

About Givaudan Fragrance & Beauty
Givaudan Fragrance & Beauty crafts inspired fragrances to perfume lives and memories, and develops innovative beauty and wellbeing solutions that make people look and feel good all over the world. Nature is both our responsibility and our most precious muse. We are just as committed to sustainability as we are to creating innovative products that satisfy consumer needs and anticipate their desires. With a collaborative approach that favours co-creation, we have built a diverse portfolio across personal care, fabric care, hygiene, home care, fine fragrances, and beauty, reflecting our multidisciplinary expertise. This is Givaudan. Human by nature. Learn more at www.givaudan.com/fragrance-beauty.

About Givaudan Active Beauty
Givaudan Active Beauty crafts avant-garde cosmetic actives and high-end specialties that make people look and feel good. We bring nature’s most precious gifts to the art of personal care in the form of biotech & botanical high-performing molecules, delighting consumers. Our extensive portfolio of award-winning skin & hair ingredients spans a variety of benefits for human beauty: from well-ageing and self-tanners to radiance, microbiome-friendly, soothers, hydrators, and more. Backed by solid scientific recognition and consumers’ awareness, we remain at the cutting edge of this rapidly expanding market to deliver sustainable solutions supporting the growth of our customers. This is Givaudan. Human by nature. Learn more at www.givaudan.com/fragrance-beauty/active-beauty.

For further information please contact
Farida Tir Teerlinck, Active Beauty Communications 
E farida.tir_teerlinck@givaudan.com